Can i take soy isoflavones and clomid together

However, only a very weak and actually inverse cross-sectional relationship was found between the isoflavone intake and age in our study sample. A direct relationship between isoflavone intake and nulliparity will be found if nulliparous women increased the intake of soy products and isoflavone to a greater degree than parous women, eg, that women with problems becoming pregnant increased their intake of soy product because they believed that these products would enhance fertility.

We have no indications that this has been the case as there were no relationships between the isoflavone intake and the proportion who reported problems becoming pregnant Table 1. This was the case in both women aged 30—40 and those aged 41—50 years.

In order to address the problem of the time lag between childbearing and the reported dietary habits, we investigated the relationship in two different groups of women, 30—year-olds and 41—year-olds. In women aged 30—40 years, the mean duration between the first delivery and completion of the questionnaire was approximately 10 years. However, women may still give birth to their first child at later ages.

Therefore, we also included a group of women aged 41—50 years who for all practical purposes have ended their childbearing when completing the questionnaire. For these women, the time period between childbearing and information on dietary habits may have been quite long a mean of approximately 20 years. However, results from both analytical cohorts indicated that a high isoflavone intake increased the likelihood of nulliparity.

The HRs given in Table 2 are estimated from the Cox regression model, essentially following the women from the age of 14 years as detailed in the Material and methods section. Thus, there is no contradiction in estimating the HRs eg, at age 26 years even though no women were below age 30 years at enrollment. We consider it a strength of this study that it is conducted in a population with extensive information on dietary habits and where the possible impact of alcohol and smoking can be virtually excluded.

Alcohol and caffeine consumption have been studied in relation to possible impact on fertility with mixed results. Women who differ with regard to diet also may differ with regard to the other variables known to have an impact on childbearing. We adjusted for not only the most important predictors for childbearing, in particular marital status and educational level, but also for race Black versus non-Black , use of oral contraceptives, BMI at age 20 years, 22 , 23 physical activity, and monthly or more frequent use of caffeinated beverages, in separate analyses.

Furthermore, stratified analyses including only women who had never smoked cigarettes or used alcohol confirmed our findings from analyses in all women. If male diet influences fertility, this may have had an impact on the associations as the spouses often conform to the same dietary pattern. The results of the analyses based on the two populations aged 30—40 and 41—50 years, respectively, seem only to differ significantly at one point, ie, with regard to a possible interaction with being a vegetarian.

However interesting, we have no obvious explanation for the seemingly different results; given the somewhat exploratory nature of our analyses and the many statistical tests conducted, we do not believe that this apparent inconsistency deserves much emphasis at this point. In summary, we find that women with a high intake of isoflavones have an increased risk of never becoming pregnant and being childless when they are at an age where they are at the end of their childbearing period aged 41—50 years.

Both sociological and biological explanations may be put forward to explain our findings. The stronger relationship in women who reported problems becoming pregnant is, in this context, interesting. However, we call for further studies, preferably prospective studies, to either refute or confirm our findings that isoflavones have a significant impact on childbearing. National Center for Biotechnology Information , U.

Int J Womens Health. Published online Apr 5. Author information Copyright and License information Disclaimer. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

This article has been cited by other articles in PMC. Abstract Objectives As little is known about the possible relationship between the intake of phytoestrogens and female fertility, we investigated the relationship between soy isoflavone intake and the risk of nulliparity and nulligravidity. Methods A cross-sectional study of 11, North American Adventist women aged 30—50 years old with data regarding childbearing.

Results The mean isoflavone intake Conclusion The findings suggest that a high dietary isoflavone intake may have significant impact on fertility. Keywords: soybeans, phytoestrogens, isoflavones, fertility, Seventh-Day Adventist. Introduction Soy products are often considered a healthy alternative to meat. Assessment of diet, vegetarian status, and the intake of soy isoflavones The food frequency questionnaire FFQ was validated against six hour dietary recalls for intake of nutrients 24 and selected foods and food groups.

Analytical cohorts Two subgroups of women from the AHS-2 study population were included in the present analyses. Statistical analyses The statistical analyses included simple cross-tabulations, analyses of variance, and correlation, as well as Cox regression and a log-binomial model.

Results In the group of women aged 30—50 years including women from both analytical cohorts , the mean age standard deviation [SD] of the women when completing the questionnaire was Table 1 Relationships between soy isoflavone intake and some variables relevant to isoflavone intake and reproduction in the Adventist Health study Open in a separate window. Table 2 Associations between soy isoflavone intake mg per day and fertility at least one live child estimated at age 26 years in the Adventist Health Study Abbreviation: CI, confidence interval.

Table 3 Associations between soy isoflavone intake mg per day and fertility at least one live child in the Adventist Health Study Table 4 Associations between soy isoflavone intake mg per day and never having been pregnant in the Adventist Health Study Discussion The main finding of this study is that women who in a Western context have a very high isoflavone intake have a somewhat increased risk of never having been pregnant or given birth to a live child.

Conclusion In summary, we find that women with a high intake of isoflavones have an increased risk of never becoming pregnant and being childless when they are at an age where they are at the end of their childbearing period aged 41—50 years. Footnotes Disclosure The authors report no conflicts of interest in this work. References 1. Patisaul HB, Jefferson W. The pros and cons of phytoestrogens. Front Neuroendocrinol.

Baber R. Thanks Mags. JuneBugsMommy, Well. Anyone get their bfp from taking these? If so how long did it take? How did these pills affect you? After reading around, I just started taking 80mg this cycle on cd2 - cd6. I'm on my 3rd day and haven't had any adverse affects yet.

I really hope this works! I'll keep you updated. First Year. In Trying to Conceive Anovulatory. Soy Isoflavones? I'm gonna start up soy iso after 2 years of HA.

I've had lots of good symptoms of hormones picking up acne, increased cm, increased sex drive but still no O. My plan is mg soy for 5 days, if all goes well and triggers O and AF I'll do another Latest: 5 months ago Tashamom7. Recommended Reading.

And if so, what was the dosage? Original poster's comments See all replies 1. Beccainalaska said:. I don't see much on it but here i…. AggieMom2BeHopefully said:. Fingers crossed my of is only having us do 5 cycles of femara before doing more testing so I am really hoping it goes well.

Fingers crossed my of is only having us do 5 cycles of femara before d…. Thanks we are on cycle two already one was a total bust no ovulation a…. Three cycles and no…. Did you do Femara and soy isoflavones together or just Femara alone?

In fact, some experts caution that ingesting highly concentrated soy products may actually inhibit fertility, especially in women who have a "normal" menstrual cycle, meaning under 35 days and regular. In those women, taking soy supplements could throw a functioning cycle out of whack. The idea is that soy isoflavones — a type of phytoestrogen, or plant-derived estrogen — may work similarly to the fertility drug clomiphene brand names Clomid and Serophene. Both act on estrogen pathways in the body and can be used to manipulate the menstrual cycle.

If you ovulate irregularly or not at all, this could kick-start ovulation. If your fertility problems are due to something else , the remedies won't help. In theory, here's how it would work. The soy isoflavones block the estrogen receptors in your brain and fool your body into thinking its natural estrogen levels are low.

In response, your body starts a cascade of events to boost estrogen production. As part of this process, a group of eggs matures so that one will be ready for release during ovulation.

After five days, you stop taking the isoflavones. Once their receptor-blocking effect wears off, your body says, "Oh, we've got lots of estrogen now — time to ovulate" and releases a hormone that triggers ovulation. This can cause health problems and make a hormone imbalance worse," says Jill Blakeway, a licensed acupuncturist and clinical herbalist and co-author of Making Babies: A Proven Three-Month Program for Maximum Fertility.

The drug clomiphene doesn't present this risk because it's specifically designed to act as an estrogen blocker. Soy isoflavones are more varied and unpredictable in their impact.